In this episode, my guest is Dr. Matthew Hill, Ph.D., a professor of cell biology and anatomy at the Hotchkiss Brain Institute at the University of Calgary and an expert on the biology of cannabis. We discuss how cannabis affects the brain to produce its psychoactive effects (feeling “high”), including altered time perception, focus, memory, appetite, and stress.We discuss how THC vs. cannabidiol (CBD) affects the brain, the effects of different routes of cannabis administration (e.g., smoking, vaping, edibles), high-potency THC, and whether cannabis is addictive. We discuss if there is a link between cannabis use and the development of psychosis, anxiety, bipolar depression, or schizophrenia. We discuss whether CBD has clinical benefits in regulating stress, promoting sleep, and treating certain diseases. We also discuss if there are real and consistent differences in the biological effects of different cannabis strains, if cannabis impacts hormones, and the uses of cannabis for the management of pain, stress, Post-traumatic stress disorder (PTSD), anxiety, and nausea.Listeners of this episode will get an up-to-date understanding of what is currently known about how cannabis affects the brain and body, including both its potential benefits and risks.Access the full show notes for this episode at hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanEight Sleep: https://www.eightsleep.com/hubermanLMNT: https://drinklmnt.com/hubermanBetterHelp: https://betterhelp.com/hubermanInsideTracker: https://insidetracker.com/hubermanTimestamps00:00:00 Dr. Matthew Hill00:00:00 Sponsors: Eight Sleep, LMNT & BetterHelp00:07:16 Cannabis, THC, Cannabidiol (CBD), Terpenes00:12:08 Psychoactive Effects, Cannabis “High”; Time Perception00:16:55 Cannabis & Brain, CB1 Receptor, Endocannabinoids00:26:19 Endocannabinoids Types: Anandamide, 2-AG00:33:46 “Munchies”, Cannabis & Appetite00:42:17 Sponsor: AG100:44:06 THC & Anandamide, Pharmacology00:52:37 THC & CB1 Receptors, Intoxication & Appetite00:58:57 Cannabis & Focus, Memory01:04:09 Routes of Administration, Concentration, Cannabis Research01:15:12 Self-Regulation, Inhalation & THC, Tolerance; THC Concentrates01:22:25 Sponsor: InsideTracker01:23:36 Addiction & Cannabis, Cannabis Use Disorder01:31:30 Cannabis Legalization & Use, Edibles & ER Visits01:36:48 Oral Consumption, Edibles, Dosing & Time Course01:41:12 Drug Testing & Cannabis, Exercise01:46:04 Cannabis & Hormones, Gynecomastia, Sperm Quality01:54:37 Cannabis & Pregnancy; Selling Recreational Cannabis02:04:07 Vaping02:07:05 Psychosis, Anxiety & Cannabis02:17:17 Cannabis, Psychosis, Schizophrenia & Genetics02:30:45 Cannabis Use & Schizophrenia, Manic Bipolar, THC Potency, Nicotine02:40:37 Schizophrenia, Cannabis Legalization02:45:06 Cannabis Strains, Indica, Sativa, Subjective Effects & Expectancy Bias02:57:00 CBD, Pediatric Epilepsy, Adenosine03:07:22 Entourage Effect; Placebo Effect, CBD & Doses03:19:12 Cannabis Health Risks, Cardiovascular Risk, Schizophrenia 03:27:08 Cyclic Vomiting Syndrome & Hot Shower03:31:30 Cannabis Benefits: Pain, Stress, Anxiety, Post-Traumatic Stress Disorder (PTSD)03:40:18 Cannabis & Anxiety, Anandamide & Stress Response03:45:55 Scientific Discussion, Clarification & Advancement03:49:47 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network NewsletterDisclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices