This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Ph.D., Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.Read the full show notes for this episode at hubermanlab.com.Thank you to our sponsorsAG1: https://athleticgreens.com/hubermanLMNT: https://drinklmnt.com/hubermanlabWaking Up: https://wakingup.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps00:00:00 Introducing Dr. Matthew Johnson  00:02:27 Sponsors: AG1, LMNT & Waking Up00:06:40 ‘Psychedelics’ Defined  00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception  00:19:56 Serotonin & Dopamine  00:23:50 Ketamine & Glutamate  00:28:00 An Example Psychedelic Experiment  00:37:30 ‘Letting Go’ with Psychedelics  00:44:10 Our Mind’s Eye  00:48:00 Redefining Your Sense of Self  00:58:56 Exporting Psychedelic Learnings to Daily Life  01:04:36 Flashbacks  01:12:10 Ayahuasca, ASMR, Kundalini Breathing  01:15:54 MDMA, DMT  01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis  01:38:15 Micro-Dosing  01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials  02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation  02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury  02:27:45 Shifting Trends in Psychedelic Research, Academic Culture  02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork  02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements  Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices