In this episode, my guest is Dr. Diego Bohórquez, PhD, professor of medicine and neurobiology at Duke University and a pioneering researcher into how we use our ‘gut sense.’ He describes how your gut communicates to your brain and the rest of your body through hormones and neural connections to shape your thoughts, emotions, and behaviors. He explains how your gut senses a range of features such as temperature, pH, the macro- and micronutrients in our foods, and much more and signals that information to the brain to affect our food preferences, aversions, and cravings.Dr. Bohórquez describes his early life in the Amazon jungle and how exposure to traditional agriculture inspired his unique expertise combining nutrition, gastrointestinal physiology, and neuroscience. We discuss how the gut and brain integrate sensory cues, leading to our intuitive “gut sense” about food, people, and situations. This episode provides a scientific perspective into your gut sense to help you make better food choices and, indeed, to support better decision-making in all of life.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanJoovv: https://joovv.com/hubermanLMNT: https://drinklmnt.com/hubermanHelix Sleep: https://helixsleep.com/hubermanInsideTracker: https://insidetracker.com/hubermanTimestamps00:00:00 Dr. Diego Bohórquez00:02:37 Sponsors: Joovv, LMNT & Helix Sleep; YouTube, Spotify & Apple Subscribe00:06:49 Gut-Brain Axis00:11:35 Gut Sensing, Hormones00:15:26 Green Fluorescent Protein; Neuropod Cells & Environment Sensing00:26:57 Brain & Gut Connection, Experimental Tools & Rabies Virus00:35:28 Sponsor: AG100:37:00 Neuropod Cells & Nutrient Sensing00:43:55 Gastric Bypass Surgery, Cravings & Food Choice00:51:14 Optogenetics; Sugar Preference & Neuropod Cells01:00:29 Gut-Brain Disorders, Irritable Bowel Syndrome01:03:03 Sponsor: InsideTracker01:04:04 Gut & Behavior; Gastric Bypass, Cravings & Alcohol01:07:38 GLP-1, Ozempic, Neuropod Cells01:11:46 Food Preference & Gut-Brain Axis, Protein01:21:35 Protein & Sugar, Agriculture & ‘Three Sisters’01:25:16 Childhood, Military School; Academics, Nutrition & Nervous System01:36:15 Plant Wisdom, Agriculture, Indigenous People01:41:48 Evolution of Food Choices; Learning from Plants01:48:15 Plant-Based Medicines; Amazonia, Guayusa Ritual & Chonta Palm01:56:58 Yerba Mate, Chocolate, Guayusa02:00:22 Brain, Gut & Sensory Integration; Variability02:06:01 Electrical Patterns in Gut & Brain, “Hangry”02:12:43 Gut Intuition, Food & Bonding; Subconscious & Superstition02:22:00 Vagus Nerve & Learning, Humming02:26:46 Digestive System & Memory; Body Sensing02:32:51 Listening to the Body, Meditation02:40:12 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network NewsletterDisclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices