In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive. We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan. Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk. Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan.Access the full show notes for this episode at hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps00:00:00 Dr. Peter Attia, NAD Pathway00:02:31 Sponsors: LMNT, Levels & Eight Sleep00:06:38 Categories of Longevity Approaches00:17:22 Peter’s Supplements; Rapamycin & Research Data00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho00:30:35 Sponsor: AG100:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol00:53:31 Perform with Dr. Andy Galpin Podcast00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits01:30:38 Longevity, NR & NMN Supplementation, Inflammation01:41:00 Rapamycin & Immune Function01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor 01:55:24 Radiation & Cancer Risk01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline02:07:12 Tool: Exercise Timing & Energy Levels02:11:22 Peter’s Supplements02:18:46 Andrew’s Supplements02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy 02:26:52 NAD Pathway Supplementation for Longevity?02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network NewsletterDisclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices